健康栄養医学研究室

細胞分子レベル業績

  1. Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H. Gastroenterology 138:1988-96, 2010.
  2. CFTR functions as a bicarbonate channel in pancreatic duct cells. Ishiguro H, Steward MC, Naruse S, Ko SB, Goto H, Case RM, Kondo T, Yamamoto A. J Gen Physiol 133:315-26, 2009.
  3. Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct. Stewart AK, Yamamoto A, Nakakuki M, Kondo T, Alper SL, Ishiguro H. Am J Physiol Gastrointest Liver Physiol 296:G1307-17, 2009.
  4. High glucose inhibits HCO3- and fluid secretion in rat pancreatic ducts. Futakuchi S, Ishiguro H, Naruse S, Ko SB, Fujiki K, Yamamoto A, Nakakuki M, Song Y, Steward MC, Kondo T, Goto H. Pflügers Arch 459:215-26, 2009.
  5. Molecular and cellular regulation of pancreatic duct cell function. Steward MC, Ishiguro H. Curr Opin Gastroenterol 25:447-53, 2009.
  6. Effects of Slc26a6 deletion and CFTR inhibition on HCO3- secretion by mouse pancreatic duct. Song Y, Ishiguro H, Yamamoto A, Jin CX, Kondo T. J Med Invest 56 Suppl:332-5, 2009.
  7. Apical Cl-/HCO3- exchanger stoichiometry in the modeling of HCO3- transport by pancreatic duct epithelium. Yamaguchi M, Ishiguro H, Steward M, Sohma Y, Yamamoto A, Shimouchi A, Kondo T. J Med Invest 56 Suppl:325-8, 2009.
  8. Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis. Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H. J Med Invest 56 Suppl:318-21, 2009.
  9. Glucose transport in interlobular ducts isolated from rat pancreas. Futakuchi S, Ishiguro H, Naruse S, Ko SB, Fujiki K, Yamamoto A, Nakakuki M, Song Y, Steward MC, Kondo T, Goto H. J Med Invest 56 Suppl:308-11, 2009.
  10. ΔFマウスとslc26a6 nullマウスを用いたHCO3-分泌機構の解析　石黒　洋、山本明子、近藤孝晴　膵臓23:25-30, 2008.
  11. Identification of key residues that cause differential gallbladder response to PACAP and VIP in the guinea pig. Wei M, Fujiki K, Ando E, Zhang S, Ozaki T, Ishiguro H, Kondo T, Nokihara K, Wray V, Naruse S. Am J Physiol Gastrointest Liver Physiol 292:G76-83, 2007.
  12. Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct. Ishiguro H, Namkung W, Yamamoto A, Wang Z, Worrell RT, Xu J, Lee MG, Soleimani M. Am J Physiol Gastrointest Liver Physiol 292:G447-55, 2007.
  13. Cystic fibrosis transmembrane conductance regulator and SLC26 transporters in HCO3- secretion by pancreatic duct cells. Ishiguro H, Steward M, Naruse S. Sheng Li Xue Bao, Acta Physiologica Sinica (Chinese Journal of Physiology) 59:465-76, 2007.
  14. 膵外分泌調節機構　石黒　洋、山本明子　別冊・医学のあゆみ　消化器疾患Ver.3－states of arts　II.肝・胆・膵　228-230, 2006.
  15. Mechanisms of Bicarbonate Secretion in the Pancreatic Duct. Steward MC, Ishiguro H, Case RM. Annu Rev Physiol 67:377-409, 2005.
  16. Dual effects of n-alcohols on fluid secretion from guinea-pig pancreatic duct cells. Hamada H, Ishiguro H, Yamamoto A, Shimano-Futakuchi S, Ko SB, Yoshikawa T, Goto H, Kitagawa M, Hayakawa T, Seo T, Naruse S. Am J Physiol Cell Physiol 288:C1431-9, 2005.
  17. CFTRによる重炭酸イオン分泌とその機能障害　石黒　洋、山本明子、成瀬　達　細胞37:305-308, 2005.
  18. アルコールによる膵液の過分泌とpH変化の細胞・分子メカニズム　石黒　洋、山本明子、後藤秀実、 近藤孝晴、成瀬　達　消化器科38(6):601-605, 2004.
  19. Ethanol induces fluid hypersecretion from guinea-pig pancreatic duct cells. Yamamoto A, Ishiguro H, Ko SB, Suzuki A, Wang Y, Hamada H, Mizuno N, Kitagawa M, Hayakawa T, Naruse S. J Physiol 551:917-26, 2003.
  20. Pancreatic bicarbonate secretion. Case RM, Ishiguro H, Steward MC. In: Encyclopedia of Gastroenterology (Johnson Leonard R, ed.) pp. 38-40, 2003. Academic Press.
  21. Membrane potential and bicarbonate secretion in isolated interlobular ducts from guinea-pig pancreas. Ishiguro H, Steward MC, Sohma Y, Kubota T, Kitagawa M, Kondo T, Case RM, Hayakawa T, Naruse S. J Gen Physiol 120:617-28, 2002.
  22. Distribution of aquaporin 1 in the rat pancreatic duct system examined with light- and electron-microscopic immunohistochemistry. Furuya S, Naruse S, Ko SB, Ishiguro H, Yoshikawa T, Hayakawa T. Cell Tissue Res 308:75-86, 2002.
  23. Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas. Ishiguro H, Naruse S, Kitagawa M, Mabuchi T, Kondo T, Hayakawa T, Case RM, Steward MC. J Physiol 539:175-89, 2002.
  24. Aquaporins in rat pancreatic interlobular ducts. Ko SB, Naruse S, Kitagawa M, Ishiguro H, Furuya S, Mizuno N, Wang Y, Yoshikawa T, Suzuki A, Shimano S, Hayakawa T. Am J Physiol Gastrointest Liver Physiol 282:G324-31, 2002.
  25. 5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells. Suzuki A, Naruse S, Kitagawa M, Ishiguro H, Yoshikawa T, Ko SB, Yamamoto A, Hamada H, Hayakawa T. J Clin Invest 108:749-56, 2001.
  26. Pancreatic ductal bicarbonate secretion: past, present and future. Ishiguro H, Naruse S, San Roman JI, Case M, Steward MC. JOP 2(4 Suppl):192-7, 2001.
  27. CO2 permeability and bicarbonate transport in microperfused interlobular ducts isolated from guinea-pig pancreas. Ishiguro H, Naruse S, Kitagawa M, Suzuki A, Yamamoto A, Hayakawa T, Case RM, Steward MC. J Physiol 528:305-15, 2000.
  28. Effects of an inhibitor of myosin light chain kinase on amylase secretion from rat pancreatic acini. Mizuno N, Naruse S, Kitagawa M, Ishiguro H, Hayakawa T. Biochem Biophys Res Commun 269:792-7, 2000.
  29. Effects of phospholipase A2 inhibitors on Ca2+ oscillations in pancreatic acinar cells. Mizuno N, Naruse S, Kitagawa M, Ishiguro H, Hayakawa T. Pancreas 20:77-83, 2000.
  30. Luminal ATP stimulates fluid and HCO3- secretion in guinea-pig pancreatic duct. Ishiguro H, Naruse S, Kitagawa M, Hayakawa T, Case RM, Steward MC. J Physiol 519:551-8, 1999.
  31. Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells. Ko SB, Naruse S, Kitagawa M, Ishiguro H, Murakami M, Hayakawa T. Am J Physiol Gastrointest Liver Physiol 277:G48-54, 1999.
  32. Fluid secretion in interlobular ducts isolated from guinea-pig pancreas. Ishiguro H, Naruse S, Steward MC, Kitagawa M, Ko SB, Hayakawa T, Case RM. J Physiol 511:407-22, 1998.
  33. 膵導管細胞―肝胆膵構成細胞の分離培養法とその応用　石黒　洋、成瀬　達、北川元二、洪　繁、早川哲夫　肝胆膵35(6):909-916, 1997.
  34. Accumulation of intracellular HCO3- by Na+-HCO3- cotransport in interlobular ducts from guinea-pig pancreas. Ishiguro H, Steward MC, Lindsay AR, Case RM. J Physiol 495:169-78, 1996.
  35. Bicarbonate secretion in interlobular ducts from guinea-pig pancreas. Ishiguro H, Steward MC, Wilson RW, Case RM. J Physiol 495:179-91, 1996.
  36. The effect of pituitary adenylate cyclase activating polypeptide (PACAP) on amylase secretion from guinea pig pancreatic acini. Kitagawa M, Naruse S, Ishiguro H, Hayakawa T, Nokihara K. Biomed Pept Proteins Nucleic Acids 1:73-6, 1995.
  37. The effect of somatostatin analogue octreotide on amylase secretion from mouse pancreatic acini. Ishiguro H, Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, Sobajima H, Nakae Y, Tanikawa M. Digestion 54:207-12, 1993.
  38. Effects of calmodulin inhibitors on amylase secretion from rat pancreatic acini. Ishiguro H, Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, Sobajima H, Nakae Y, Tanikawa M, Hidaka H. Digestion 53:162-70, 1992.

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